(b. 1926), B.Sc. 1949, M.Sc. 1950, University of Sydney; Ph.D. 1952, Oxford University.

Cu rrent research includes stereochemistry and NMR spectroscopy.

Isotope effects on chemical shifts, particularly those of a conformational (equilibrium) origin are under investigation. For example, we have shown that compound I sho ws observably diastereotopic protons in the monodeuteriated methyl group. In collaboration with Professor H. G. Floss (University of Washington) and his research group, this work has led to an NMR method for directly determining the configuration of a CHDT group by means of tritium NMR. The method is based on the fact that the tritium NMR chemical shifts in II and III are observably different.

In collaboration with Professor J. E. Baldwin (Syracuse Univer sity) and his research group, we have shown that predictable conformational isotope effects allow the quantitative analysis of mixtures of stereochemically different trideuteriated cyclopentenes produced by the vinyl cyclopropane-cyclopentene rearrange ment.

Novel relaxation effects in NMR spectroscopy have been discovered and studied. In collaboration with Professor Martin Saunders (Yale University) and his research group, we have shown that [3]He NMR of endoh edrally trapped helium in fullerenes can be observed and provides new and important evidence about the magnetic properties of the fullerenes.

The conformations of cyclic molecules are being studied experimentally by NMR and theoreticall y by molecular mechanics and ab initio quantum mechanical methods.

Representative Publications

(1) F. A. L. Anet and D. J. O'Leary, "NMR Line Shapes Caused by Transverse Cross Relaxation of Nearly Like Spins," J. Magn. Reson., 86, 358 (1990).

(2) F. A. L. Anet, "A General Definition of Axial, Equatorial and Related Terms for Substituents on Rings of any Size," Tetrahedron Lett., 31, 2125 (1990).

(3) F. A. L. Anet, D. J. O'Le ary, C. G. Wade, and R. D. Johnson, " NMR Relaxation by the Antisymmetric Component of the Shielding Tensor: A Longer Transverse than Longitudinal Relaxation Time," Chem. Phys. Lett., 171, 401 (1990).

(4) F. A. L. Anet, "Inflection P oints and Chaotic Behavior in Searching the Conformational Space of Cyclononane," J. Am. Chem. Soc., 112, 7172 (1990).

(5) F. A. L. Anet, D. J. O'Leary, and P. G. Williams, "Tritium NMR in Conformational Analysis: Isotopic Perturbat ion of the Ring Inversion Equilibrium in [3H]-Cyclohexane," J. Chem. Soc., Chem. Commun., 1427 (1990).

(6) F. A. L. Anet and D. J. O'Leary, "The Shielding Tensor, Part I: Understanding its Symmetry Properties," Co ncepts in Magn. Reson. 3, 193 (1991).

(7 F. A. L. Anet and D. J. O'Leary, "The Shielding Tensor, Part II: Understanding its Strange Effects on Relaxation," Concepts in Magn. Reson. 4, 35 (1992).

(8) F. A. L. Anet an d J. Park, "Proton Chemical Shift Assignments in Citrate and Trimethyl Citrate in Chiral Media," J. Am. Chem. Soc., 114, 411 (1992).

(9) F. A. L. Anet, D. I. Freedberg, J. W. Storer, and K. N. Houk, "On the Potential Energy Surface f or Ring Inversion in Cyclohexene and Related Molecules," J. Am. Chem. Soc., 114, 10969 (1992).

(10) F. A. L. Anet and D. I. Freedberg, "Traditional Averaging of NMR Parameters in the Fast Exchange Limit is Valid!," Chem. Phys. Le tt. 208, 187 (1993).

(11) M. Saunders, H. A. Jiminez-Vazquez, R. J. Cross, S. Mroczkowski, D. I. Freedberg, F. A. L. Anet, "Probing the Interior of Fullerenes by [3]He NMR Spectroscopy of Endohedral [3]He@C60 and [3]He@C70," Nature, 367, 256, (1994).

(12) M. Saunders, H. A. Jiminez-Vazquez, B. W. Bangerter, R. J. Cross, S. Mroczkowski, D. I. Freedberg, and F. A. L. Anet "[3]He NMR: a Powerful New Tool for Following Fullerene Chemistry" J. Am. Chem. Soc., 115, 3621 (1994).

(13) M. Buhl, W. Thiel, H. J. Jiao, P. V. Schleyer, M. Saunders, F. A. L. Anet, "Helium and Lithium NMR Chemical Shifts of Endohedral Fullerene Compounds - An ab initio Study," J. Am. Chem. Soc., 116, 6005 (1994).

(14) J. E. Baldwin, K. A. Villarica, D. A. Freedberg, and F. A. L. Anet, "Stereochemistry of the Thermal Isomerization of Vinylcyclopr opene to Cyclopentene," J. Am. Chem. Soc., 116, 10845 (1994).

[ Department * Faculty* Current Organic Research* Anet Biography* Organic Research Interests ]