From my Group (2014- Present)

 

55. Roy K, Gabunilas J, Gillespie A, Ngo D, Chanfreau GF. Common genomic elements promote transcriptional and DNA replication roadblocks. Genome Res. 2016 Aug 18. [Epub ahead of print].

54. Gabunilas J, Chanfreau G. Splicing-Mediated Autoregulation Modulates Rpl22p Expression in Saccharomyces cerevisiae. PLoS Genet. 12(4):e1005999 (2016). eCollection 2016 Apr.

53. Hodko D, Ward T, Chanfreau G. The Rtr1p CTD phosphatase autoregulates its mRNA through a degradation pathway involving the REX exonucleases. RNA. 22(4):559-70 (2016). Epub 2016 Feb 3.

52. Al-Hadid Q, Roy K, Chanfreau G, Clarke SG. Methylation of yeast ribosomal protein Rpl3 promotes translational elongation fidelity. RNA. 22(4):489-98 (2016). Epub 2016 Jan 29.

51. Kaweeteerawat C., Chang CH, Roy KR, Liu R, Li R, Toso D, Fischer H, Ivask A, Ji Z, Zink JI, Zhou ZH, Chanfreau GF, Telesca D, Cohen Y, Holden PA, Nel AE, Godwin H. Cu Nanoparticles Have Different Impacts in Escherichia coli and Lactobacillus brevis than Their Microsized and Ionic Analogues. ACS Nano. 9(7):7215-25 (2015). Epub 2015 Jul 13.

50. Chanfreau G. Two degrading decades for RNA. RNA 21(4): 584-5 (2015).

49. Roy K, Chanfreau G. Stress-induced nuclear RNA degradation pathways regulate yeast bromodomain factor 2 to promote cell survival. PLoS Genet. 10(9):e1004661 (2014). eCollection 2014 Sep.

48. Dzialo MC, Travaglini KJ, Shen S, Roy K, Chanfreau GF, Loo JA, Clarke SG. Translational roles of elongation factor 2 protein lysine methylation. J Biol. Chem. 289(44):30511-24 (2014). Epub 2014 Sep 17.

47. Al-Hadid, Q., Roy, K., Munroe, W., Dzialo, M.C., Chanfreau, G.F., Clarke, S.G. (2014) Histidine Methylation of Yeast Ribosomal Protein Rpl3p Is Required for Proper 60S Subunit Assembly. Mol Cell Biol. Aug 1;34(15):2903-16.

46. Kawashima, T., Douglass, S., Gabunilas, J., Pellegrini, M., Chanfreau, G.F. (2014) Widespread use of non-productive alternative splice sites inSaccharomyces cerevisiae. PLoS Genet. Apr 10;10(4):

From my Group (2001-2013)

 

45. Chanfreau, G.F. (2013) Zinc'ing down RNA Polymerase I. Transcription. 2013 Sep 27;4(5).

44. Lee, Y.J., Lee, C.Y., Grzechnik, A., Gonzales-Zubiate, F., Vashisht, A.A., Lee, A., Wohlschlegel, J., Chanfreau, G.F. (2013) RNA Polymerase I Stability Couples Cellular Growth to Metal Availability. Mol Cell. Jul 11;51(1):105-15.

43. Hartman, E., Wang, Z., Zhang, Q., Roy, K., Chanfreau, G., Feigon, J. (2013) Intrinsic dynamics of an extended hydrophobic core in the S. cerevisiae RNase III dsRBD contributes to recognition of specific RNA binding sites. J Mol Biol. Feb 8;425(3):546-62.

42. Lee, Y.J., Huang, X., Kropat, J., Henras, A., Merchant, S.S., Dickson, R.C., Chanfreau, G.F. (2012) Sphingolipid signaling mediates iron toxicity. Cell Metab. Jul 3;16(1):90-6.

41. Sayani, S., Chanfreau, G.F. (2012) Sequential RNA degradation pathways provide a fail-safe mechanism to limit the accumulation of unspliced transcripts in Saccharomyces cerevisiae. RNA. Aug;18(8):1563-72.

40. Egecioglu, D.E., Kawashima, T.R., Chanfreau, G.F. (2012) Quality control of MATa1 splicing and exon skipping by nuclear RNA degradation. Nucleic Acids Res. Feb;40(4):1787-96.

39. Wang, Z., Hartman, E., Roy, K., Chanfreau, G., Feigon, J. (2011) Structure of a Yeast RNase III dsRBD Complex with a Noncanonical RNA Substrate Provides New Insights into Binding Specificity of dsRBDs. Structure. Jul 13;19(7):999-1010.

38. Toesca, I., Nery, C.R., Fernandez, C.F., Sayani, S., Chanfreau, G.F. (2011) Cryptic transcription mediates repression of subtelomeric metal homeostasis genes. PLoS Genet. Jun;7(6).

37. Koo, B.K., Park, C.J., Fernandez, C.F., Chim, N., Ding, Y., Chanfreau, G., Feigon, J. (2011) Structure of H/ACA RNP Protein Nhp2p Reveals Cis/Trans Isomerization of a Conserved Proline at the RNA and Nop10 Binding Interface. J Mol Biol. 2011 Jun;411(5):927-42.

36. Egecioglu, D.E., Chanfreau, G. (2011) Proofreading and spellchecking: A two-tier strategy for pre-mRNA splicing quality control. RNA. Mar;17(3):383-9.

35. Chanfreau, G.F. (2010) A dual role for RNA splicing signals. EMBO Rep. Oct;11(10):720-1.

34. Chanfreau, G. (2010) InvIGOrating mRNAs during Quiescence. Mol Cell. May 14;38(3):317-8.

33. Kawashima, T., Pellegrini, M., Chanfreau, G.F. (2009) Nonsense-mediated mRNA decay mutes the splicing defects of spliceosome component mutations. RNA. Dec;15(12):2236-47.

32. Singh, M., Gonzales, F.A., Cascio, D., Heckmann, N., Chanfreau, G., Feigon, J. (2009) Structure and functional studies of the CS domain of the essential H/ACA RNP assembly protein Shq1. J Biol Chem. 284, 1906-1916.  

31. Sayani, S., Janis, M., Lee, C.Y., Toesca, I., Chanfreau, G.F. (2008) Widespread impact of nonsense-mediated mRNA decay on the yeast intronome.Mol Cell. Aug 8;31(3):360-70.

30. Merchant, S.S., et al. (2007) The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions. Science 318:245-250. Online supporting information.

29. Oberstrass, F.C., Lee, A., Stefl, R., Janis, M., Chanfreau, G., Allain, F.H. (2006) Shape-specific recognition in the structure of the Vts1p SAM domain with RNA. Nat Struct Mol Biol. Feb;13(2):160-7. 

28 . Egecioglu, D.E., Henras, A.K., Chanfreau, G. (2006) Contributions of Trf4p- and Trf5p-dependent polyadenylation to the processing and degradative functions of the yeast nuclear exosome. RNA. Jan;12(1):26-32. 

27. Chanfreau, G. (2005) CUTting genetic noise by polyadenylation-induced RNA degradation. Trends Cell Biol. Dec;15(12):635-7.

26: Zer, C., Chanfreau, G. (2005) Regulation and surveillance of normal and 3'-extended forms of the yeast aci-reductone dioxygenase mRNA by RNase III cleavage and exonucleolytic degradation. J Biol Chem. Aug 12;280(32):28997-9003.

25: Lee, A., Henras, A.K., Chanfreau, G. (2005) Multiple RNA surveillance pathways limit aberrant expression of iron uptake mRNAs and prevent iron toxicity in S. cerevisiae. Mol Cell. Jul 1;19(1):39-51.

24: Henras, A.K., Sam, M., Hiley, S.L., Wu, H., Hughes, T.R., Feigon, J., Chanfreau, G. (2005) Biochemical and genomic analysis of substrate recognition by the double-stranded RNA binding domain of yeast RNase III. RNA. Aug;11(8):1225-37.

23: Yang, P.K., Hoareau, C., Froment, C., Monsarrat, B., Henry, Y., Chanfreau, G. (2005) Cotranscriptional Recruitment of the Pseudouridylsynthetase Cbf5p and of the RNA Binding Protein Naf1p during H/ACA snoRNP Assembly. Mol Cell Biol. Apr;25(8):3295-304.

22: Sam, M., Henras, A.K., Chanfreau, G. (2005) A Conserved Major Groove Antideterminant for Saccharomyces cerevisiae RNase III Recognition. Biochemistry. Mar 22;44(11):4181-7.

21: Sam, M., Hwang, J.H., Chanfreau, G., Abu-Omar, M.M. (2004) Hydroxyl radical is the active species in photochemical DNA strand scission by bis(peroxo)vanadium(V) phenanthroline. Inorg Chem. Dec 27;43(26):8447-55.

20: Henras, A.K., Bertrand, E., Chanfreau, G. (2004) A cotranscriptional model for 3'-end processing of the Saccharomyces cerevisiae pre-ribosomal RNA precursor. RNA. Oct;10(10):1572-85.

19: Wu, H., Henras, A., Chanfreau, G., Feigon, J. (2004) Structural basis for recognition of the AGNN tetraloop RNA fold by the double-stranded RNA-binding domain of Rnt1p RNase III. Proc Natl Acad Sci U S A. Jun 1;101(22):8307-12.

18: Lee, C.Y., Lee, A., Chanfreau, G. (2003) The roles of endonucleolytic cleavage and exonucleolytic digestion in the 5'-end processing of S. cerevisiae box C/D snoRNAs. RNA. Nov;9(11):1362-70.

17: Chanfreau, G. (2003) Conservation of RNase III processing pathways and specificity in hemiascomycetes. Eukaryot Cell. Oct;2(5):901-9.

16: Danin-Kreiselman, M., Lee, C.Y., Chanfreau, G. (2003) RNAse III-mediated degradation of unspliced pre-mRNAs and lariat introns. Mol Cell. May;11(5):1279-89.

15: Yang, P.K., Rotondo, G., Porras, T., Legrain, P., Chanfreau, G. (2002) The Shq1p.Naf1p complex is required for box H/ACA small nucleolar ribonucleoprotein particle biogenesis. J Biol Chem. Nov 22;277(47):45235-42.

14: Wu H, Yang PK, Butcher SE, Kang S, Chanfreau G, Feigon J. (2001) A novel family of RNA tetraloop structure forms the recognition site for Saccharomyces cerevisiae RNase III. EMBO J. Dec 17;20(24):7240-9. Link to AGNN tetraloop structures

From research during my CNRS Position

(1998-2000)

 

13. Kufel, J.l, Allmang, C., Chanfreau, G., Petfalski, E., Lafontaine, D. L.J. , Tollervey, D. (2000) Precursors to the U3 Small Nucleolar RNA Lack Small Nucleolar RNP Proteins but Are Stabilized by La Binding. Mol. Cell. Biol. 20: 5415-5424.

12. Chanfreau,G., Buckle, M., Jacquier, A. (2000) Recognition of a conserved class of RNA tetraloops by yeast RNase III. Proc. Natl. Acad. Sci. 97: 3142-3147.

11. Allmang, C., Kufel, J., Chanfreau, G., Mitchell, P., Petfalski, E., Tollervey, D. (1999) Functions of the exosome in rRNA, snoRNA and snRNA synthesis. EMBO J. 18: 5399-5410.

10. Chanfreau, G., Gouyette,C., Schwer,B., Jacquier, A. (1999) Trans-complementation of the second step of pre-mRNA splicing by exogenous 5' exons.RNA 5: 876-882.

9. Chanfreau, G., Rotondo, G., Legrain, P., Jacquier, A. (1998) Processing of a dicistronic small nucleolar RNA precursor by the RNA endonuclease Rnt1. EMBO J. 17: 3726-3737.

8. Chanfreau, G., Legrain, P., Jacquier, A. (1998) Yeast RNase III as a key processing enzyme in small nucleolar RNAs metabolism. J. Mol. Biol. 284: 975-988.

From my Post-Doctoral Research

(Mentor: Christine Guthrie)

 

7. Chanfreau, G., Abou Elelea, S., Ares, M., Guthrie, C. (1997) Alternative 3'-end processing of U5 snRNA by RNase III. Genes & Dev. 11: 2741-2751.

6. Chanfreau, G., Noble, S., Guthrie, C. (1996) Essential Yeast Protein with unexpected similarity to subunits of cleavage and polyadenylation specificity factor (CPSF). Science 274: 1511-1514.

5. Nolte, A., Chanfreau, G., Jacquier, A. (1998) Influence of substrate structure on in vitro ribozyme activity of a group II intron. RNA 4: 694-709.

4. Chanfreau, G., Jacquier, A. (1996) An RNA conformational change between the two chemical steps of group II self-splicing. EMBO J. 15: 3466-3476.

3. Chanfreau, G., Jacquier, A. (1994) Catalytic site components common to both splicing steps of a group II intron. Science 266: 1383-1387.

2. Chanfreau, G., Legrain, P., Dujon, B., Jacquier, A. (1994) Interaction between the first and last nucleotides of pre-mRNA introns is a determinant of 3' splice site selection in S. cerevisiae. Nucleic Acids Res. Jun 11;22(11):1981-7.

1. Chanfreau, G., Jacquier, A. (1993) Interaction of intronic boundaries is required for the second splicing step efficiency of a group II intron. EMBO J. 12: 5173-5180.