Lecture Schedule
| Week | Date | Topic | Pages in Text | Links |
|---|---|---|---|---|
| 1 | Mon, Jan 3 | Introduction & overview [pdf] [pptx] | 1-42 | Inner Life of a Cell movie - Molecular art by David Goodsell |
| Tue, Jan 4 | Water, Acid-base chemistry [pdf] [pptx] | 43-58, 65-66 | ||
| Wed, Jan 5 | Acid-base chemistry, Buffers, Amino acids [pdf] [pptx] | 58-64, 78-81 | Protein pI predictor | |
| Fri, Jan 6 | Amino acids [pdf] [pptx] | 71-78 | ||
| 2 | Mon, Jan 10 | Peptides and proteins [pdf] [pptx] | 82-4, 113-5 | |
| Tue, Jan 11 | Protein sequence (primary structure) and evolution [pdf] [pptx] | 92-4, 102-6 | RefSeq - UniProt - Blast | |
| Wed, Jan 12 | Protein sequence and conformation [pdf] [pptx] | 115-128 | Article on The discovery of the alpha-helix and beta-sheet | |
| Fri, Jan 14 | Carbohydrates: mono- and disaccharides [pdf] [pptx] | 235-244 | ||
| 3 | Mon, Jan 17 | Martin Luther King Holiday | ||
| Tue, Jan 18 | Protein secondary and tertiary structure [pdf] [pptx] | 120-131 | Hydropathy plot tool | |
| Wed, Jan 19 | Protein tertiary and quaternary structure and folding
[pdf]
[pptx] Carbohydrates: disaccharides and intro to polysaccharides [pdf] [pptx] |
135-143, 145-148 | Protein Data Bank (PDB) Fold It - a computer game of protein folding |
|
| Fri, Jan 21 | Carbohydrates: oligo and polysaccharides [pdf] [pptx] | 244-263 | ||
| 4 | Mon, Jan 24 | Carbohydrates: glycoconjugates
[pdf]
[pptx] Lipids [pdf] [pptx] |
343-363, 513 | |
| Tue, Jan 25 | Membranes [pdf] [pptx] | 371-375, 381-386 | ||
| Wed, Jan 26 | Membrane proteins [pdf] [pptx] | 375-380, 389-396 | ||
| Fri, Jan 28 | Methods in biomolecular structure analysis [pdf] [pptx] | 94-100, 122, 132-4, 263-5, 365-6 |
||
| 5 | Mon, Jan 31 | Molecular binding and allostery [pdf] [pptx] | 153, 155-7, 162, 164-5 | |
| Tue, Feb 1 | Myoglobin and Hemoglobin [pdf] [pptx] | 154-5, 157-160 | Hemoglobin (with links to PDB structure files) | |
| Wed, Feb 2 | Hemoglobin: oxygen binding and effectors [pdf] [pptx] | 161, 163-4, 165-170 | ||
| Fri, Feb 4 | Hemoglobin continued; Intro to Enzymes | |||
| 6 | Mon, Feb 7 | Enzyme classification and mechanisms of catalysis [pdf] [pptx] | 183-194, 495-501, 210-211 | Enzyme commission naming |
| Tue, Feb 8 | Mechanisms continued; Lysozyme [pdf] [pptx] | 213-216 | PyMOL molecular structure viewer Lysozyme (with links to PDB structure files) |
|
| Wed, Feb 9 | Lysozyme continued; Serine proteases [pdf] [pptx] | 205-209 | ||
| Fri, Feb 11 | Serine proteases continued; Reaction kinetics | |||
| 7 | Mon, Feb 14 | Enzyme kinetics | 194-201 | |
| Tue, Feb 15 | Kinetics of enzyme inhibition [pdf] [pptx] | 201-204 | ||
| Wed, Feb 16 | Enzyme Regulation [pdf] [pptx] | 220-228 | ||
| Fri, Feb 18 | Intro to Metabolism [pdf] [pptx] | 485-488 | ||
| 8 | Mon, Feb 21 | Presidents' Day Holiday | ||
| Tue, Feb 22 | Energetics of metabolism; Energy currencies [pdf] [pptx] | 489-495 | ||
| Wed, Feb 23 | Energy currencies continued (see yesterday's slides) | 501-511, 516-521 | ||
| Fri, Feb 25 | Glycolysis - preparatory phase [pdf] [pptx] | 527-535 | ||
| 9 | Mon, Feb 28 | Glycolysis - payoff phase [pdf] [pptx] | 535-538 | |
| Tue, Mar 1 | Regulation of Glycolysis; Gluconeogenesis; Fermentation [pdf] [pptx] | 539, 546-558, 569-577 | ||
| Wed, Mar 2 | Aerobic metabolism overview; Pyruvate dehydrogenase complex [pdf] [pptx] | 615-620 | ||
| Fri, Mar 4 | Citric acid cycle [pdf] [pptx] | 620-630 | ||
| 10 | Mon, Mar 7 | Citric acid cycle regulation [pdf] [pptx] | 630-638 | |
| Tue, Mar 8 | Intro to oxidative phosphorylation; reduction potentials [pdf] [pptx] | 707-712, 512-516 | ||
| Wed, Mar 9 | Electron transport [pdf] [pptx] | 712-721 | ||
| Fri, Mar 11 | ATP synthase [pdf] [pptx] | 723-731 | ATP synthase movie |