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Current Faculty    
James U. Bowie David S. Eisenberg Joseph A. Loo
Guillaume Chanfreau Juli Feigon Harold G. Martinson
Catherine F. Clarke James W. Gober Sabeeha Merchant
Steven G. Clarke Jay D. Gralla Emil Reisler
Robert T. Clubb Wayne L. Hubbell Joan S. Valentine
Albert J. Courey Carla M. Koehler Richard L. Weiss
Richard E. Dickerson Christoper J. Lee Todd O. Yeates
Emeriti Faculty      
Daniel E. Atkinson Paul D. Boyer Verne N. Schumaker Charles A. West
Structural Biology & Bioinformatics Map of UCLA UCLA Home Page
James U. Bowie
Associate Professor
Protein folding and structure; Sequence determinants of protein structure are explored by a combination of genetic, biophysical, and computational approaches

Office - (310) 206-4747
Lab - (310) 206-4748
Fax - (310) 206-4749
655 Boyer Hall

bowie@mbi.ucla.edu

Guillaume Chanfreau
Assistant Professor
RNA processing and metabolism in eukaryotes; RNA-Protein interactions; RNA endonucleases

Office - (310) 825-4399
Lab - (310) 825-8412
4042A Young Hall

guillom@chem.ucla.edu

Catherine F. Clarke
Professor
Biosynthesis, regulation and function of ubiquinone (coenzyme Q); characterization of genes in the ubiquinone biosynthetic pathway; interspecific complementation of yeast ubiquinone mutants;
anti-oxidant defense mechanisms

Office - (310) 825-0771
Lab - (310) 825-7327
5072B Young Hall

cathy@mbi.ucla.edu
Steven G. Clarke
Professor
Protein methylation reactions in eukaryotic cells; non-enzymatic degradation reactions of proteins; biochemistry of aging; signal transduction
Office - (310) 825-8754
Lab - (310) 825-3137
640 Boyer Hall

clarke@mbi.ucla.edu
Robert T. Clubb
Assistant Professor
Structural studies of proteins and protein complexes using heteronuclear multidimensional NMR spectroscopy; Biochemical characterization of proteins involved in DNA recombination and repair

Office - (310) 206-2334
Lab - (310) 206-4038
656 Boyer Hall

rclubb@mbi.ucla.edu
Albert J. Courey
Professor
Transcriptional regulation; biochemical and molecular genetic analysis of pattern formation during fruit fly embryogenesis
Office - (310) 825-2530
Lab - (310) 206-4982
5040B Young Hall

courey@chem.ucla.edu
Richard E. Dickerson
Professor
X-ray studies of nucleic acids and proteins; sequence/structure relationships in double-helical DNA; binding of anti-tumor drugs and recognition proteins to DNA; evolution of macromolecules and metabolic pathways

Office - (310) 825-5864
Lab - (310) 206-8278
255A Boyer Hall

red@mbi.ucla.edu
David S. Eisenberg
Professor
Study of biochemical macromolecules by X-ray diffraction and computational methods; structure and action of enzymes and of membrane-related proteins; protein folding and the atomic basis of biological recognition
Office - (310) 825-3754
Lab - (310) 825-8901
201A Boyer Hall

david@mbi.ucla.edu
Juli Feigon
Professor
Conformational studies of nucleic acids using multidimensional NMR techniques: DNA triplexes and quadruplexes; drug-DNA complexes, DNA and RNA aptamers; DNA and RNA-protein complexes

Office - (310) 206-6922
Lab - (310) 825-9232
Fax - (310) 825-0982
256 Boyer Hall

feigon@mbi.ucla.edu
James W. Gober
Associate Professor
Transcriptional regulation during cell differentiation in Caulobacter; genetics and biochemistry of cell cycle and polar gene expression; DNA higher-order structure and transcriptional activation; chromosome structure
Office - (310) 206-9449
Lab - (310) 206-5684
5072C Young Hall

gober@chem.ucla.edu
Jay D. Gralla
Professor
The role of nucleic acid-protein complexes in cellular controls; repression and activation of transcription; mechanism of action of anti-cancer drugs that attack DNA; chemical probes of DNA structure

Office - (310) 825-1620
Lab - (310) 825-9881
440 Boyer Hall

gralla@mbi.ucla.edu

Wayne L. Hubbell
Professor

Molecular mechanisms of membrane transduction and switching processes, primarily visual transduction and voltage dependent membrane gating systems. Development of spectroscopic approaches for the study of membrane structure, dynamics and electrostatic phenomena
Office - (310) 206-8830
Lab - (310) 206-8831
3-219 Jules Stein Eye Inst.

hubbellw@jsei.ucla.edu
Carla M. Koehler
Assistant Professor

Genetic and biochemical studies of protein import into mitochondria, role of mitochondrial biogenesis in cellular functions and disease

Office - (310) 794-4834
Lab - (310) 825-8427
4041A Young Hall

koehlerc@chem.ucla.edu

Christopher J. Lee
Assistant Professor
Bioinformatics and genomics: genome sequence analysis; computational methods for identification of single nucleotide polymorphisms; genomics databases; prediction of protein structure and function
Office - (310) 825-7374
Lab - (310) 794-4026
601A Boyer Hall

leec@chem.ucla.edu
Joseph A. Loo
Professor
Development of novel bioanalytical methods for the characterization of proteins and their post-translational modifications and their application for drug discovery and proteomics. Development and application of electrospray ionization mass spectrometry for the study of noncovalently-bound macromolecular complexes and their interactions with inhibitors. Fundamentals of analytical chemistry and mass spectrometry.
Office - (310) 794-7023
402 Boyer Hall

jloo@chem.ucla.edu
Harold G. Martinson
Professor
Mechanism of cleavage and polyadenylation of pre-mRNA and its role in signaling transcription termination in eukaryotic cells

 

Office - (310) 825-3767
Lab - (310) 825-4916
5040A Young Hall

hgm@chem.ucla.edu
Sabeeha Merchant
Professor
Copper and iron homeostasis; re-modelling of the photosynthetic apparatus in iron-deficiency; mechanisms of copper sensing and signal transduction; cytochrome c biogenesis; chloroplast metabolism; photosynthesis

Office - (310) 825-8300
Lab - (310) 825-3661
Fax - (310) 206-1035
5070A Young Hall

merchant@chem.ucla.edu

Emil Reisler
Professor
Structure and function of contractile proteins; protein-protein and protein-ligand interactions; mechanism of muscle contraction; mechanism of ATP hydrolysis; self assembly of myosin and actin

Office - (310) 825-2668
Lab - (310) 825-4585
402 Boyer Hall

reisler@mbi.ucla.edu
Joan S. Valentine
Professor
Bioinorganic chemistry study of the reactivity and other properties of transition metal complexes that are analogues of metalloenzyme active sites; study of structure-function relationships in the enzyme copper-zinc superoxide dismutase using site-directed mutagenesis; biochemistry of oxygen, superoxide, and peroxide

Office - (310) 825-9835
Lab - (310) 825-2807
Fax - (310) 206-7197
1505A Mol. Sci. Bldg.

jsv@chem.ucla.edu

Richard L. Weiss
Professor
Compartmentation of enzymes and metabolites; molecular genetics, metabolic and genetic regulation in eukaryotic microorganisms
Office - (310) 825-3621
Lab - (310) 206-0946
5072A Young Hall

weiss@chem.ucla.edu

Todd O. Yeates
Professor
Three-dimensional structure and function of proteins by X-ray diffraction; computational analysis of macromolecules

Office - (310) 206-4866
Lab - (310) 825-8901
202 Boyer Hall

yeates@mbi.ucla.edu

Emeriti Faculty


Daniel E. Atkinson
Emeritus Professor
Cellular energy metabolism and its regulation

Office - (310) 825-1159
2069 Young Hall

dea@ucla.edu

Paul D. Boyer
Emeritus Professor
Bioenergetics of ATP synthesis

Office - (310) 825-1466
639A Boyer Hall

pdboyer@ucla.edu
Verne N. Schumaker
Emeritus Professor
Surface architecture of serum lipoproteins using monoconal antibodies, and the structure of the gene coding for apolipoprotein B; mechanism of activation of the first component of complement, and the role of segmental flexibility in the immune system; expression of complement proteins
Office - (310) 825-3531
Lab - (310) 825-8760
3060 Young Hall

schumak@mbi.ucla.edu
Charles A. West
Emeritus Professor
Plant biochemistry; regulation of the biosynthesis of isoprenoid compounds with physiological activity including disease resistance agents and the gibberellin family of growth regulators; diterpene metabolism, studies of molecular mechanisms involved in plant disease resistance
Office - (310) 825-1255
4048 Young Hall

west@chem.ucla.edu

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