Illustrated Glossary of Organic Chemistry
Nucleophilic
aromatic
substitution
(NAS):
A
substitution reaction
in which attack on an
aromatic
ring by a
nucleophile
replaces a
substituent
(or in the case of the
Chichibabin reaction
a
hydride ion
) on that
aromatic
ring.
Reaction of
o
-fluoro
nitro
benzene
with
methoxide ion
(a
nucleophile
) follows the
S
N
Ar nucleophilic aromatic substitution reaction mechanism
.
Related terms:
Ipso substitution
,
electrophilic aromatic substitution
,
EAS
,
Sanger's reagent
,
S
N
2 mechanism
,
S
N
1 mechanism
,
nucleophilic carbonyl substitution
,
nucleophilic acyl substitution,
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