Illustrated Glossary of Organic Chemistry
Calicheamicin:
An
enediyne
DNA cutter
. Initial
anticancer
studies with this
molecule
were encouraging because the required dose was very low, but it ultimately proved too toxic for clinical use.
Molecular structure
of calicheamicin.
Related terms:
Bergman cyclization
,
free radical
,
diradical
,
benzyne
,
aromatic
,
benzene ring
,
erythromycin
Wikipedia entry
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