Illustrated Glossary of Organic Chemistry
Arbuzov reaction (Michaelis-Arbuzov reaction):
A reaction between a tri
alkyl
phosphite and an
alkyl halide
to
produce
a phosphonate. The
reaction mechanism
involves a pair of
S
N
2
steps.
(CH
3
CH
2
O)
3
P
+
CH
3
I
+
CH
3
CH
2
I
Tri
ethyl
phosphite
Methyl
iodide
Di
ethyl
methyl
phosphonate
Ethyl
iodide
In this Arbuzov reaction, tri
ethyl
phosphite is reacted with
methyl
iodide to
produce
di
ethyl
methyl
phosphonate and
ethyl
iodide.
Related terms:
Phosphate
,
diphosphate
,
triphosphate
,
polyphosphate
,
phosphate ester
,
phosphate group
,
phosgene
,
phosphatidic acid
,
phosphatidyl choline
,
phosphine
,
phosphine oxide
,
phosphodiester
,
phospholipid
,
phospholipid bilayer
,
phosphonium salt
,
phosphonium ylide
,
phosphoric acid
,
phosphorylation
,
Michael reaction
,
Michael addition
Wikipedia entry
Return to glossary index
