last updated Friday, October 31, 2003

Problem set  Meeting 12


1. In this week's multistep synthesis, during the Grignard step, water should be excluded as much as possible. How do you accomplish that?

2. Ice and dry ice are used in the reaction.

a. What is dry ice? Are there any safety precautions?

b. Why do you use dry ice in the Grignard reaction?

c. Why do you use ice during the work-up?

3. How can you minimize the formation of biphenyl in the reaction?

4. During the Grignard work-up, aqueous sodium hydroxide is used. Why?

5. How can you initiate the reaction? How do you know that the reaction started?

6. What is Cadet's Liquid?