Problems Set (Meeting 10)

General Announcements

Make sure that you turn in a hardcopy of your research paper by Thursday February 17, 2006 at 5 pm and the electronic version to turnitin.com as well (CourseID: 1415142, Passwd: Chem30CL for Winter2006). Late reports will be deducted points (10% per day including the weekend). If you do not submit the report online by Monday February 20, 2006 at 10 pm, you will receive a "zero" score for the paper. In addition, it will be reported to the Dean of Students. Any plagiarism, partial or full resubmission of a papers or/and other forms of cheating will result in a report to the Dean of Students as well. Make sure that you cite your sources and try to use your own words as much as possible. Here is a checklist what should be included into the report. If you have any questions, please contact your TA or instructor asap, and not an hour before the submission deadline.

The next quiz will be administered on Thursday February 9, 2006 at 12 pm.

Questions

1. Referring to the conversion of a-Chloro-2,6-dimethylacetanilide to licocaine, answer the following questions. Show pertinent chemical equations.

a. Three equivalents of the amine are used in the reaction. Rationalize this choice.

b. The reaction mixture is extracted with water and hydrochloric acid. Which purpose does this serve?

c. How is the water removed from the lidocaine after the precipitation?

2. Why are anhydrides more reactive than acids?

3. Which evidence can an experimenter provide to verify the presence of a C-N double bond in amides?