Announcements

1. Make sure that you make progress on your formal report as well in terms of literature search and writing the parts that you completed already in the lab.

2. The next will be administered on Tuesday April 18, 2006 at 12 pm. The material covered will mainly include the ligand and the resolution step. Please make sure that you show up on time.

3. The draft version of paper is due on 4-28-2006 at 5 pm. The draft version is worth 15 points, the final paper 45 points. For more information what the draft is supposed to contain see here. Late submission will receive less credit. The more of your work you submit here, the more feedback you will get, which will beneficial for the final version. We will try to return the reports by Monday.

ATTN: Answers to the below questions are due at the start of your lab period; these answers should be part of your pre-lab write-up.

1. Referring to the synthesis and characterization of the Jacobsen catalyst, answer the following questions.

a. How can the reaction time be optimized for this reaction?

b. How does the experimenter know that the reaction is proceeding?

c. Why is heptane added during the workup?

d. What are the most important changes in the IR spectrum of the catalyst?

e. A student plans to acquire the UV-Vis spectrum for the catalyst in the range from 200-700 nm. Determine the appropriate concentration. Which solvent and which cuvette should be used?

2. Referring to the design of the catalyst, anser the following questions.

a. Why is manganese used as the metal center here and not zinc?

b. In which way are cytochrome P₄₅₀ and Jacobsen's catalyst similar in their catalytic activity?

c. What is the function of the tert.-butyl group in the 5-position?

d. Why does the (R,R)-form of the catalyst afford one enantiomer in the epoxidation?