last updated Saturday, January 15, 2011

1. Draw the equations for the resolution step (shown on page 43 of the reader) and the catalyst synthesis (shown on page 45 of the reader). In addition, draw the reaction equation of the ferrocene acylation (shown on page 99 of the reader). Once you are done drawing the three equations transfer them to a word document. Rescale and center them on the page.

2. Type the following text in Word.

"Since the reaction is very slow even if a catalyst is present, the reaction mixture has to be heated in order to obtain a reasonable yield within the time frame allotted. According to the Arrhenius equation, the rate of reaction roughly doubles with each 10 °C increase in temperature!

However, both the forward and reverse reactions are affected, so Keq is not changed. Only the rate at which the equilibrium is reached is dramatically increased. In the experiment, the temperature is raised by 40-80 oC (depending which alchol is used) by refluxing it, which increases the rate of reaction by a factor of ~16-256. Even under those conditions, the reaction mixture should be refluxed for at least 60-90 minutes."

3. Using the ACD-Spectra simulation software in Chemdraw, simulate the 1H-NMR spectrum and the 13C-NMR spectrum for the Jacobsen ligand. Can this data serve as literature data?