updated last Friday, January 27, 2006
Week 4 Problem Set - 30BL (Turn in your computer assignment during week 5)
- Include Part I into your prelab. DO PROBLEMS (II-IIII) DURING YOUR ASSIGNED LAB PERIOD.
- ANSWERS TO THESE QUESTIONS ARE TO BE DONE IN YOUR LAB NOTEBOOK.
- This assignment is worth 10 points and should take between 45-60 minutes to complete.
- Bring a black, blue and red pen (or crayon or pencil).
- ATTENTION: PC_Spartan 2002 application has a problem printing sometimes!
BUT THERE IS AN ALTERNATIVE FOR PRINTING
FROM SPARTAN. Here's what do:
- Open a blank document in MS Word.
- Copy the molecule from Spartan (Ctrl C)
- Paste into Word
- And print -- voila!
Part I: Phase Transfer Oxidation (due in prelab)
1. A student acquires a GC spectrum for his final compound. He dissolves his compound in dichloromethane and observes the following results.
| Time (min) |
Height (pA) |
Width (min) |
| 1.2 |
10000 |
0.2 |
| 3.25 |
50 |
0.1 |
| 5.50 |
20 |
0.2 |
a. Which conclusion can he draw about the composition of his final product?
b. He used an HP-5 column and ran the GC at T=100 oC. Which conclusions can he draw about his compound(s) ?
c. How could he determine which of the observed peaks belongs to his target compound?
d. The second peak at t=5.50 min not as high, yet has a wider on the base. Rationalize this observation.
2. A separatory funnel is used this week during the work-up. Answer the following questions.
a. Which tests should be performed prior to using the separatory funnel?
b. The procedure asks to vent the separatory funnel frequently during the extraction. What does this mean, how is it done and why?
c. Why do most separatory funnels have a pear-shaped appearance?
3. Referring to the reaction carried out in the lab, answer the following questions.
a. Assuming that bleach is used in excess, how could one test if the reaction is completed?
b. What is the function of (NBu4)(HSO4) in the reaction?
c. Assuming that you have about 40 mL of solution after the extraction, which contains 6% of water (by volume), how many grams of anhydrous sodium sulfate should be used here? Show your work.
d. At some point the procedure asks to remove the solvent. Which precautions should be taken here?
e. The crude product purified using column chromatography. Outline a brief procedure.
PART II. (Reduction of Camphor, In-lab assignment)
This assignment is to be completed in the UCLA Science Learning Center computing labs during the lab period (or afterwards if you don't complete it in the allotted time). The assignment is due during meeting 5 and is worth 10 points.
1. Optimize the above structural geometry of borneol, camphor and isoborneol. (see below instructions). Compare the heat of formation of borneol and isoborneol. Which one is thermodynamically more stable? How can you rationalize the differences?
2. Determine the dipol moment for borneol, camphor and isoborneol. (see below instructions). In the GC spectrum, camphor has the shortest retention time, then isoborneol and borneol last. Can you rationalize the GC results based on the calculated dipole momenta of these compounds? (Note: The GC column is relatively non-polar.) Do not apply any constraints in this part!
Instructions:
- Build, minimize and save the structure. (don't forget to Minimize the structure after building it!!)
this is the minimize button. Always minimize your structure before leaving the building mode.
- click on
to enter View Mode
- Select Calculations from the Setup menu.
The following window should appear. Select the options shown.
Verify the Charge is Neutral and Multiplicity is Singlet. Click OK.
- Select Submit from Setup menu.
- When the calculation is completed you will be notified.
- Select Output from the Display menu.
Record the heat of formation value given
See these Helpful Hints for manipulating structures!
Note:
| 1 au = 1 hartree = 627.5 kcal/mol |
| 1 eV = 23.06 kcal/mol |
| 1 hartree = 27.21 eV |
| 1 Ångstrom = 1.889762 atomic units = 10-8 cm |
PART III. (Aldol Condensation, In-lab assignment)
|
1. Calculate the dipole moment for dihedral angles:
0 through 180 degrees in 15 degree increments.
Plot the dipole moment of benzil vs. the dihedral angle.
|
Newman Projection of Benzil
|
Instructions:
- click on Constrain Dihedral angle tool,
- select the atoms shown below in the specific sequence O..C..C..O. This will define two planes O1C1C2 and C1C2O2, which are going to be rotated towards each other in this part.
- Click on the lock tool,
, in the bottom right corner so that it looks like this, 
- Set the dihedral angle to 0 and hit the ENTER key.
- click on the minimize tool,
, and wait for the operation to complete.
- click on the minimize tool, , a second time and wait for the operation to complete.
- Select Calculations from the Setup menu. The following window should appear. Select the options shown.
- Make sure the
- Click OK to close the window.
- Select Submit from Setup menu. When the calculation is completed you will be notified.
- Under the Display menu, select Properties.
- A window should appear (the values in this example should differ from yours). If there are no values in the window then you need to double click on the molecule.
- Record the dipole moment and energy given. (In this example the dipole = 3.9 debye).
- Calculate the dipole moment for dihedral angles: 0 through 180 degrees in 15 degree increments. (Hint: Just click on the pink bond and change the value in the box.). Do not define a new constraint at this point. This will confuse the program completely!
- For the higher angles (>120 degrees), you might have to uncheck the symmetry box in the setup calculation menu. However, sometimes it works better if the approach is for the higher angles is from 180 degrees going down.
- Using EXCEL, plot the dipole moment and energy of benzil vs. the dihedral angle (use MS Excel, XY Scatter plot). Rationalize the observed trends.