Illustrated Glossary of Organic Chemistry
No reaction (NR):
A circumstance in which mixing of
reactants
causes no change in
molecular structure
. Frequently abbreviated as
NR
.
No reaction
Tert
-butyl
chloride does not react with
cyanide ion
(a
nucleophile
) in
acetone
(a
nonpolar
aprotic
solvent
) because chloride (the
leaving group
) is
bonded
to a
tertiary carbon
, and there is too much
steric hindrance
for the
S
N
2 mechanism
to occur.
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