YVES RUBIN
Associate Professor; Diploma in Chemistry, University of Fribourg, Switzerland; PhD, University of California, Los Angeles; Swiss National Science
Foundation Postdoctoral Fellow, Columbia University; Camille and Henry Dreyfus New Faculty Award.
Research Description
Our research program is motivated by the need of creating and exploring new organic materials for future exciting technological applications such as superconductivity, magnetism, molecular electronics, and medicine.
We put emphasis on modern synthetic and physical-organic chemistry to solve these important problems. Our current research effort is directed toward the total synthesis of buckminsterfullerene (C60) and particularly its endohedral metal com
plexes, using a strategy in which a metal ion
is encapsulated in a synthetic precursor prior to full closure to the C60-framework. The use of water-soluble endohedral C60-complexes enclosing radioactive elements for diagnostic and therapeutic applications is
investigated as well as those containing paramagnetic imaging agents (e.g. gadolinium) for magnetic resonance imaging (MRI). The clear advantage of
these complexes is that the metal is encapsulated within the very stable and rigid C60-framework, thus preventing metal toxicity in vivo. For this purpose, we are studying methods for the preparation of addition compounds
to C60. The attachment of functional groups on C60 has already allowed us to prepare several water-soluble amino acid derivatives, which may be used to anchor C60 to proteins or enzymes.
We are also interested in the preparation of organic ferromagnets based on two- and three-dimensional high spin networks constructed from new stable
organic radicals and manganese(II) complexes. The ground spin states of the new radicals and the bulk magnetic properties of the complexes will be extensively studied.
Key Words
Organic Chemistry: materials science; fullerene chemistry; synthesis
and derivatization of buckminsterfullerene and higher fullerenes; C60-based compounds of biological and physical organic interest; chemistry of
bowl-shaped aromatic hydrocarbons; acetylenic chemistry; inorganic
and organometallic derivatives; organic ferromagnets.
[ Department*
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Revision: 08/23/95 // burns@chem.ucla.edu
